Conventional ‘bulk’ methods of RNA sequencing (RNA-seq) process. And at the cutting edge of the field is single-cell RNA sequencing (scRNA-seq). Single-cell biology is a hot topic these days. This seemingly paradoxical result was due to GVHD being driven by different types. observed that STING promoted GVHD in mouse models of MHC-matched aHSCT. Stimulator of interferon genes (STING) is important for gut homeostasis and has been shown to be protective against experimental GVHD after MHC-mismatched allogeneic hematopoietic stem cell transplantation (aHSCT).